Dienogest is as effective as leuprolide acetate in treating the painful symptoms of endometriosis: a 24-week, randomized, multicentre, open-label trial

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Dienogest is as effective as leuprolide acetate in treating the painful symptoms of endometriosis: a 24-week, randomized, multicentre, open-label trial.

BACKGROUND Dienogest is a selective progestin that has been investigated in a clinical trial programme for the treatment of endometriosis. The current non-inferiority trial compared the efficacy and safety of dienogest against leuprolide acetate (LA) for treating the pain associated with endometriosis. METHODS Patients with confirmed endometriosis were randomized to treatment with dienogest (...

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Dienogest and deep infiltrating endometriosis: The remission of symptoms is not related to endometriosis nodule remission.

OBJECTIVE To evaluate the effectiveness of dienogest in controlling pain caused by deep infiltrating endometriosis (DIE), its influence on the quality of live (QoL) of women affected by the disease, and the effect of the drug on the volume of endometriotic lesions. STUDY DESIGN A prospective cohort study including 30 women with a sonographic diagnosis of DIE (intestinal and posterior fornix) ...

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ژورنال

عنوان ژورنال: Human Reproduction

سال: 2010

ISSN: 0268-1161,1460-2350

DOI: 10.1093/humrep/dep469